Depressant overdoses, especially when taken with alcohol, may lead to which serious condition?

Depressant overdoses, particularly when consumed alongside alcohol, can result in respiratory depression, leading to the body's inability to adequately oxygenate tissues. This critical condition can escalate quickly into unconsciousness and, ultimately, death. The combined effects of depressants and alcohol amplify their sedative properties, which significantly increase the risk of overdose. The central nervous system becomes severely impaired, affecting vital functions such as breathing and heart rate. This makes death a significant concern in cases of depressant overdose, particularly because users may not be aware of the dangers of mixing these substances or may misjudge the amounts they are consuming. Understanding this risk is crucial for prevention and safety in dealing with such substances.